منابع مشابه
Lipoic acid in secondary progressive MS
Objective: To determine whether lipoic acid (LA), an endogenously produced antioxidant, slowed the whole-brain atrophy rate and was safe in secondary progressive MS (SPMS). Methods: Patients with SPMS aged 40–70 years enrolled in a single center, 2-year, double-blind, randomized trial of daily oral 1,200mg LA vs placebo. Primary outcomewas change in annualized percent change brain volume (PCBV)...
متن کاملLipoic Acid Pharmacokinetics at Baseline and 1 year in Secondary Progressive MS
Lipoic acid (LA) is a waterand fat-soluble oral antioxidant with anti-inflammatory properties. It has demonstrated benefits in animal models of MS and has been evaluated for MS relapse prevention and neuroprotection. However, there are relatively a few data regarding LA pharmacokinetics (PK) in elderly populations or with use beyond 4 days. In addition, studies have used a variety of doses, a w...
متن کاملAlpha-Lipoic Acid
OBJECTIVE: To evaluate the efficacy and safety of oral treatment with the antioxidant alpha-lipoic acid (ALA) in NIDDM patients with cardiac autonomic neuropathy (CAN), assessed by heart rate variability (HRV). RESEARCH DESIGN AND METHODS: In a randomized, double-blind placebo-controlled multicenter trial (Deutsche Kardiale Autonome Neuropathie [DEKAN] Study), NIDDM patients with reduced HRV we...
متن کاملAlpha Lipoic Acid
Alpha lipoic acid, or just lipoic acid (LA), is a unique and potent antioxidant. It can deliver antioxidant activity in both fatand water-soluble mediums, and it is capable of having an antioxidant effect in both its oxidized (LA) and reduced (DHLA [dihydrolipoic acid]) forms (Goraca et al., 2011). This effectively allows LA to deliver its antioxidant effect to any cell or tissue type, as well ...
متن کاملAlpha-lipoic Acid Monograph
Introduction Alpha-lipoic acid (ALA – also known as thioctic acid) was discovered in 1951 as a molecule that assists in acyl-group transfer and as a coenzyme in the Krebs cycle. In the 1980s, the scientific community realized alpha-lipoic acid is a powerful antioxidant. Several qualities distinguish alpha-lipoic acid from other antioxidants: ALA can be synthesized by animals and humans;1 it neu...
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ژورنال
عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation
سال: 2017
ISSN: 2332-7812
DOI: 10.1212/nxi.0000000000000374